Anti-Human Furin Recombinant Nanobody (SAA1180) (HY484013)

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50ug
100ug
1mg

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概述
图片
参考文献
产品说明书

概述

货号

HY484013

品牌

abinScience

描述

Anti-Human FURIN Nanobody (SAA1180) [SAA1180] (HY484013) is a alpaca monoclonal antibody detecting FURIN in ELISA, IP, SPR. Suitable for Human.

Highlights

●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IP, SPR

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1180

靶标

FUR, PCSK3, PACE, FURIN, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, Furin

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

P09958

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Furin is a ~86 kDa protein. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells.

1. Anderson, ED. et al. (2002) The Journal of biological chemistry 277, 12879-90. PMID: 11799113

2. Leduc, R. et al. (1992) The Journal of biological chemistry 267, 14304-8. PMID: 1629222

3. Barr, PJ. et al. (1991) DNA and cell biology 10, 319-28. PMID: 1713771

4. Wise, RJ. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9378-82. PMID: 2251280

5. Dahms, SO. et al. (2014) ACS chemical biology 9, 1113-8. PMID: 24666235

6. Hardes, K. et al. (2015) ChemMedChem 10, 1218-31. PMID: 25974265

7. Takahashi, S. et al. (1995) The Journal of biological chemistry 270, 26565-9. PMID: 7592877

8. Takahashi, S. et al. (1993) Biochemical and biophysical research communications 195, 1019-26. PMID: 7690548

9. Anderson, ED. et al. (1997) The EMBO journal 16, 1508-18. PMID: 9130696

10. Dubois, CM. et al. (1995) The Journal of biological chemistry 270, 10618-24. PMID: 7737999

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human FURIN Nanobody (SAA1180)

参考文献

产品说明书

Anti-Human Furin Recombinant Nanobody (SAA1180).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Furin Recombinant Nanobody (SAA1180) (HY484013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Furin Recombinant Nanobody (SAA1180) (HY484013)

概述

图片

参考文献

产品说明书

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