Complement factor H (CFH) is a ~139 kDa protein. Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. 1. Kajander, T. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2897-902. PMID: 212853682. Morgan, HP. et al. (2011) Nature structural & molecular biology 18, 463-70. PMID: 213178943. Blaum, BS. et al. (2015) Nature chemical biology 11, 77-82. PMID: 254027695. Kennedy, AT. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 1239-48. PMID: 267007686. Hocking, HG. et al. (2008) The Journal of biological chemistry 283, 9475-87. PMID: 182527127. Simon, N. et al. (2013) Cell host & microbe 13, 29-41. PMID: 233321548. Xue, X. et al. (2017) Nature structural & molecular biology 24, 643-651. PMID: 286716649. Losse, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 912-21. PMID: 2000829510. DiScipio, RG. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 4057-66. PMID: 9558116 | 
