Anti-Human CD31/PECAM1 Recombinant Antibody (SAA2178), PE (HB004127)

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概述

货号	HB004127
品牌	abinScience
描述	Anti-Human CD31/PECAM1 Recombinant Antibody (SAA2178), PE (HB004127) is a mouse monoclonal antibody detecting CD31/PECAM-1 in FCM. Suitable for Human. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●PE Conjugated — Ready for direct detection without secondary antibody.
种属反应性	Human
应用	FCM
宿主	Mouse
克隆类型	Monoclonal
同种型	VHH-mFc (IgG2a)
克隆号	SAA2178
偶联物	PE
靶标	Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1
内毒素水平	Please contact with the lab for this information.
纯度	>90% as determined by SDS-PAGE.
相关产品	VHH-mFc Isotype Control Antibody (cAb-Lys2), PE
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P16284
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. 1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684 3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302 4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892 5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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参考文献

产品说明书

Anti-Human CD31/PECAM1 Recombinant Antibody (SAA2178), PE.pdf

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Anti-Human CD31/PECAM1 Recombinant Antibody (SAA2178), PE (HB004127)

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Anti-Human CD31/PECAM1 Recombinant Antibody (SAA2178), PE (HB004127)

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