Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO) (HY286096)

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概述

货号	HY286096
品牌	abinScience
描述	Zenocutuzumab (HY286096) is a research-grade recombinant antibody targeting CD340. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
表达系统	Mammalian cells
经测试应用	WB, FCM
靶标	p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P04626 & P21860
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Bispecific, MCLA-128, PB4188, R040517, 1969309-56-5
背景	Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Bioactivity

Detects CD340/ERBB2/HER2/NEU in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Zenocutuzumab
Flow CytoMetry

Flow-cytometry using anti-human ERBB3 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ERBB3 monoclonal antibody (Catalog: HY286096) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-CD340/ERBB2 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human CD340/ERBB2 (Catalog No: HY286011)

参考文献

产品说明书

Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO).pdf

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质量

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C₁ × V₁ = C₂ × V₂

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母液

C₁ (起始浓度)

V₁ (起始体积)

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C₂ (终浓度)

V₂ (终体积)

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Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO) (HY286096)

概述

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参考文献

产品说明书

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实验相关试剂

Anti-Human ErbB2/Her2 & ErbB3/Her3 Bispecific Reference Antibody (Zenocutuzumab, RUO) (HY286096)

概述

图片

参考文献

产品说明书

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