Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO) (HF004206)

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概述
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概述

货号	HF004206
品牌	abinScience
描述	Izalontamab (HF004206) is a research-grade recombinant antibody targeting HER1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa-[scFv-heavy-lambda]2
表达系统	Mammalian cells
经测试应用	FCM
靶标	HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P00533 & P21860
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	Tetravalentbispecific, SI-1, SI-1X6.4, SI-B001, 2559704-24-2
背景	Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Bioactivity

Detects EGFR in indirect ELISA.
Flow cytometry

Flow-cytometry using anti-human ERBB3 antibody. HepG2 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB3 monoclonal antibody (Catalog HF004206, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

参考文献

产品说明书

Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

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母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

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Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO) (HF004206)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO) (HF004206)

概述

图片

参考文献

产品说明书

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