Protein A/G purified from cell culture supernatant.
Accession号
Q07011 & P04626
状态
Liquid
保存溶液
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
产品使用信息
应用方法
稀释比例
WB
1:500-1:2000
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.
Note
For research use only. Not suitable for clinical or therapeutic use.
Detects recombinant CD340 (Catalog No: HY286011) in indirect ELISA.
Bioactivity
Detects recombinant CD137 (Catalog No: HC336011) in indirect ELISA.
Western blot
Western blot analysis was performed using anti-CD137 monoclonal antibody at 1ug/mL on various samples. Lane 1: recombinant human CD137 (Catalog No: HC336011) Lane 2: Negative control
