Anti-PTH1R Polyclonal Antibody (HX947014)

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概述
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参考文献
产品说明书

概述

货号

HX947014

品牌

abinScience

描述

Anti-PTH1R Polyclonal Antibody (HX947014) is a rabbit polyclonal antibody detecting PTH1R in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human PTH1R (Ala28-Gly188).

靶标

PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTHR1, PTHR, PTH1 receptor, PTH/PTHrP type I receptor, PTH1R, Parathyroid hormone/parathyroid hormone-related peptide receptor

纯化方式

Purified by antigen affinity column.

Accession号

Q03431

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) is a ~66 kDa protein. G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH.

1. Grauschopf, U. et al. (2000) Biochemistry 39, 8878-87. PMID: 10913300

2. Pioszak, AA. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 5034-9. PMID: 18375760

3. Pioszak, AA. et al. (2009) The Journal of biological chemistry 284, 28382-28391. PMID: 19674967

4. Shimomura-Kuroki, J. et al. (2017) Odontology 105, 150-154. PMID: 27160269

5. Zhao, LH. et al. (2019) Science (New York, N.Y.) 364, 148-153. PMID: 30975883

6. Kobayashi, K. et al. (2022) Molecular cell 82, 3468-3483.e5. PMID: 35932760

7. Schneider, H. et al. (1993) European journal of pharmacology 246, 149-55. PMID: 8397094

8. Pioszak, AA. et al. (2010) The Journal of biological chemistry 285, 12435-44. PMID: 20172855

Note

For research use only.

图片

参考文献

产品说明书

Anti-PTH1R Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PTH1R Polyclonal Antibody (HX947014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PTH1R Polyclonal Antibody (HX947014)

概述

图片

参考文献

产品说明书

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