Anti-LRP8 Polyclonal Antibody (HC675014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HC675014

品牌

abinScience

描述

Anti-LRP8 Polyclonal Antibody (HC675014) is a rabbit polyclonal antibody detecting LRP8 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human LRP8 (Pro447-Ile675).

靶标

LRP8, LRP-8, Low-density lipoprotein receptor-related protein 8, APOER2, Apolipoprotein E receptor 2

纯化方式

Purified by antigen affinity column.

Accession号

Q14114

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Low-density lipoprotein receptor-related protein 8 (LRP8) is a ~105 kDa protein. Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development.

1. Andersen, OM. et al. (2003) Biochemistry 42, 9355-64. PMID: 12899622

2. Li, X. et al. (2003) Biochemistry 42, 10406-17. PMID: 12950167

3. Yasui, N. et al. (2010) Structure (London, England : 1993) 18, 320-31. PMID: 20223215

4. Dlugosz, P. et al. (2019) Frontiers in molecular neuroscience 12, 53. PMID: 30873003

5. Lutters, BC. et al. (2003) The Journal of biological chemistry 278, 33831-8. PMID: 12807892

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-LRP8 polyclonal antibody at 1ug/mL on various samples.
Lane 1: SH-SY5Y cell lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse testis lysate

参考文献

产品说明书

Anti-LRP8 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-LRP8 Polyclonal Antibody (HC675014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-LRP8 Polyclonal Antibody (HC675014)

概述

图片

参考文献

产品说明书

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