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Anti-LRP8 Polyclonal Antibody (ARO-A13809)

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概述
货号ARO-A13809
品牌ProteoGenix
描述
Anti-LRP8 Polyclonal Antibody (ARO-A13809) is a rabbit polyclonal antibody detecting LRP8, LRP-8, Low-density lipoprotein receptor-related protein 8, APOER2, Apolipoprotein E receptor 2 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human LRP8 (Pro447-Ile675).
靶标LRP8, LRP-8, Low-density lipoprotein receptor-related protein 8, APOER2, Apolipoprotein E receptor 2
纯化方式Purified by antigen affinity column.
Accession号Q14114
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Low-density lipoprotein receptor-related protein 8 (LRP8) is a ~105 kDa protein. Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development.

1. Andersen, OM. et al. (2003) Biochemistry 42, 9355-64. PMID: 12899622
2. Li, X. et al. (2003) Biochemistry 42, 10406-17. PMID: 12950167
3. Yasui, N. et al. (2010) Structure (London, England : 1993) 18, 320-31. PMID: 20223215
4. Dlugosz, P. et al. (2019) Frontiers in molecular neuroscience 12, 53. PMID: 30873003
5. Lutters, BC. et al. (2003) The Journal of biological chemistry 278, 33831-8. PMID: 12807892
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-LRP8 Polyclonal Antibody

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