

| 货号 | VK703014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 种属反应性 | Poliovirus type 1 (PV1) | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 同种型 | IgG | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant Poliovirus type 1 VP0/Capsid protein VP0 (Pro122-Gln341). | ||||||||
| 靶标 | Genome polyprotein, P1, Capsid protein VP0 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P03300 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Genome polyprotein (VP0/Capsid protein VP0) is a ~246 kDa protein. Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to target host epithelial cells. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis in Hela cells and through caveolin-mediated endocytosis in brain microvascular endothelial cells. _x005F_x000D_ _x005F_x000D_1. Hogle, JM. et al. (1985) Science (New York, N.Y.) 229, 1358-65. PMID: 2994218 _x005F_x000D_
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2. Strauss, M. et al. (2013) Journal of virology 87, 3903-14. PMID: 23365424 _x005F_x000D_
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3. Strauss, M. et al. (2015) Journal of virology 89, 4143-57. PMID: 25631086 _x005F_x000D_
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4. Brandenburg, B. et al. (2007) PLoS biology 5, e183. PMID: 17622193 _x005F_x000D_
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5. Coyne, CB. et al. (2007) The EMBO journal 26, 4016-28. PMID: 17717529 _x005F_x000D_
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6. Bergelson, JM. (2008) Trends in microbiology 16, 44-7. PMID: 18191571 _x005F_x000D_ | ||||||||
| Note | For research use only. |

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