

| 货号 | VK557010 |
|---|---|
| 品牌 | abinScience |
| 描述 |
InVivoMAb Anti-Poliovirus Capsid protein VP1 (C3) [C3] (VK557010) is a human monoclonal antibody detecting Genome polyprotein in ELISA, Neutralization.
|
| 种属反应性 | Poliovirus type 1 (PV1) |
| 应用 | ELISA, Neutralization |
| 宿主 | Human |
| 同种型 | IgG4, kappa |
| 克隆号 | C3 |
| 克隆类型 | Monoclonal |
| 靶标 | Genome polyprotein, Capsid protein VP1, Virion protein 1 |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 相关产品 | pH 7.4 Dilution Buffer |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P03300 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Genome polyprotein (Capsid protein VP1) is a ~246 kDa protein. Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to target host epithelial cells. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis in Hela cells and through caveolin-mediated endocytosis in brain microvascular endothelial cells. 1. Hogle, JM. et al. (1985) Science (New York, N.Y.) 229, 1358-65. PMID: 2994218 2. Strauss, M. et al. (2013) Journal of virology 87, 3903-14. PMID: 23365424 3. Strauss, M. et al. (2015) Journal of virology 89, 4143-57. PMID: 25631086 4. Brandenburg, B. et al. (2007) PLoS biology 5, e183. PMID: 17622193 5. Coyne, CB. et al. (2007) The EMBO journal 26, 4016-28. PMID: 17717529 6. Bergelson, JM. (2008) Trends in microbiology 16, 44-7. PMID: 18191571 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for InVivoMAb Anti-Poliovirus Capsid protein VP1 (C3).



24小时产品查询

扫一扫关注我们

专属渠道经理