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Anti-CD126/IL6R/IL-6RA Polyclonal Antibody (PTX19545)

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概述
货号PTX19545
品牌ProteoGenix
描述
Anti-CD126/IL6R/IL-6RA Polyclonal Antibody (PTX19545) is a rabbit polyclonal antibody detecting sIL6R,Interleukin-6 receptor subunit alpha,CD126,IL-6R 1,IL-6R subunit alpha,Membrane glycoprotein 80,gp80,IL6R,IL-6RA,IL-6 receptor subunit alpha,IL-6R-alpha in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CD126/IL6R/IL-6RA (Met1-Pro365).
靶标sIL6R,Interleukin-6 receptor subunit alpha,CD126,IL-6R 1,IL-6R subunit alpha,Membrane glycoprotein 80,gp80,IL6R,IL-6RA,IL-6 receptor subunit alpha,IL-6R-alpha
纯化方式Purified by antigen affinity column.
Accession号P08887
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Interleukin-6 receptor subunit alpha (CD126/IL6R) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.

1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003
2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492
3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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