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Anti-HSP90B1 Polyclonal Antibody (PTX19584)

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概述
货号PTX19584
品牌ProteoGenix
描述
Anti-HSP90B1 Polyclonal Antibody (PTX19584) is a rabbit polyclonal antibody detecting 94 kDa glucose-regulated protein,HSP90B1,gp96 homolog,GRP94,Heat shock protein 90 kDa beta member 1,Endoplasmin,TRA1,Tumor rejection antigen 1,GRP-94 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human HSP90B1 (Asp22-Ala311).
靶标94 kDa glucose-regulated protein,HSP90B1,gp96 homolog,GRP94,Heat shock protein 90 kDa beta member 1,Endoplasmin,TRA1,Tumor rejection antigen 1,GRP-94
纯化方式Purified by antigen affinity column.
Accession号P14625
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Endoplasmin (HSP90B1/GRP94) is a ~92 kDa protein. ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10.

1. Liu, B. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 6877-82. PMID: 23572575
2. Ma, M. et al. (2024) Science (New York, N.Y.) 386, 667-672. PMID: 39509507
3. Randow, F. et al. (2001) Nature cell biology 3, 891-6. PMID: 11584270
4. Zhang, M. et al. (2020) Cell 181, 637-652.e15. PMID: 32272059
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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