| 背景 | Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. 1. Tsai, YT. et al. (2000) Molecular and cellular biology 20, 2043-54. PMID: 106886512. Yamamoto, T. et al. (2002) Biochemical and biophysical research communications 297, 811-7. PMID: 123592254. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 151947005. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 156535076. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 162859607. Saxena, NK. et al. (2007) The Journal of biological chemistry 282, 13316-25. PMID: 173442148. Jiang, H. et al. (2008) Biochemical and biophysical research communications 368, 1-5. PMID: 182425809. Hou, T. et al. (2008) The Journal of biological chemistry 283, 30725-34. PMID: 18782771 |
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