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Anti-ARG2 Polyclonal Antibody (PTX18476)

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概述
货号PTX18476
品牌ProteoGenix
描述
Anti-ARG2 Polyclonal Antibody (PTX18476) is a rabbit polyclonal antibody detecting Arginase-2,mitochondrial,Type II arginase,Kidney-type arginase,Arginase II,Non-hepatic arginase,ARG2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human ARG2 (Val23-Ile354).
靶标Arginase-2,mitochondrial,Type II arginase,Kidney-type arginase,Arginase II,Non-hepatic arginase,ARG2
纯化方式Purified by antigen affinity column.
Accession号P78540
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Arginase-2, mitochondrial (ARG2/Arginase II) is a ~38 kDa protein. May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium.

1. Geiger, R. et al. (2016) Cell 167, 829-842.e13. PMID: 27745970
2. Xu, W. et al. (2016) The Journal of clinical investigation 126, 2465-81. PMID: 27214549
3. McGovern, N. et al. (2017) Nature 546, 662-666. PMID: 28614294
4. Yepuri, G. et al. (2012) Aging cell 11, 1005-16. PMID: 22928666
5. Xiong, Y. et al. (2014) Autophagy 10, 2223-38. PMID: 25484082
6. Xiong, Y. et al. (2013) Journal of the American Heart Association 2, e000096. PMID: 23832324
7. Cama, E. et al. (2003) Biochemistry 42, 8445-51. PMID: 12859189
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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