

| 货号 | PX-P5499 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Recombinant Human ARG2 Protein, N-His (PX-P5499) expressed in E. coli, Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 表达系统 | E. coli |
| Accession号 | P78540 |
| 蛋白长度 | Val23-Ile354 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 38.39 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | Arginase-2, mitochondrial, Type II arginase, Kidney-type arginase, Arginase II, Non-hepatic arginase, ARG2 |
| 背景 | Arginase-2, mitochondrial (ARG2/Arginase II) is a ~38 kDa protein. May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. 1. Geiger, R. et al. (2016) Cell 167, 829-842.e13. PMID: 27745970 2. Xu, W. et al. (2016) The Journal of clinical investigation 126, 2465-81. PMID: 27214549 3. McGovern, N. et al. (2017) Nature 546, 662-666. PMID: 28614294 4. Yepuri, G. et al. (2012) Aging cell 11, 1005-16. PMID: 22928666 5. Xiong, Y. et al. (2014) Autophagy 10, 2223-38. PMID: 25484082 6. Xiong, Y. et al. (2013) Journal of the American Heart Association 2, e000096. PMID: 23832324 7. Cama, E. et al. (2003) Biochemistry 42, 8445-51. PMID: 12859189 |
| Note | For research use only. |

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