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Anti-PTH1R Polyclonal Antibody (PTX18665)

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概述
货号PTX18665
品牌ProteoGenix
描述
Anti-PTH1R Polyclonal Antibody (PTX18665) is a rabbit polyclonal antibody detecting PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTHR1,PTHR,PTH1 receptor,PTH/PTHrP type I receptor,PTH1R,Parathyroid hormone/parathyroid hormone-related peptide receptor in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PTH1R (Ala28-Gly188).
靶标PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTHR1,PTHR,PTH1 receptor,PTH/PTHrP type I receptor,PTH1R,Parathyroid hormone/parathyroid hormone-related peptide receptor
纯化方式Purified by antigen affinity column.
Accession号Q03431
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) is a ~66 kDa protein. G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH.

1. Grauschopf, U. et al. (2000) Biochemistry 39, 8878-87. PMID: 10913300
2. Pioszak, AA. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 5034-9. PMID: 18375760
3. Pioszak, AA. et al. (2009) The Journal of biological chemistry 284, 28382-28391. PMID: 19674967
4. Shimomura-Kuroki, J. et al. (2017) Odontology 105, 150-154. PMID: 27160269
5. Zhao, LH. et al. (2019) Science (New York, N.Y.) 364, 148-153. PMID: 30975883
6. Kobayashi, K. et al. (2022) Molecular cell 82, 3468-3483.e5. PMID: 35932760
7. Schneider, H. et al. (1993) European journal of pharmacology 246, 149-55. PMID: 8397094
8. Pioszak, AA. et al. (2010) The Journal of biological chemistry 285, 12435-44. PMID: 20172855
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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