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Anti-Human CERS2 Polyclonal Antibody (PTX20552)

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概述
货号PTX20552
品牌ProteoGenix
描述
Anti-Human CERS2 Polyclonal Antibody (PTX20552) is a rabbit polyclonal antibody detecting SP260, CERS2, LASS2, CerS2, TMSG1, Ceramide synthase 2, LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein, Sphingosine N-acyltransferase CERS2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CERS2 (Asn81-Ser128).
靶标SP260, CERS2, LASS2, CerS2, TMSG1, Ceramide synthase 2, LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein, Sphingosine N-acyltransferase CERS2
纯化方式Purified by antigen affinity column.
Accession号Q96G23
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ceramide synthase 2 (CERS2) is a ~44 kDa protein. Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions.

1. Lahiri, S. et al. (2007) FEBS letters 581, 5289-94. PMID: 17977534
2. Laviad, EL. et al. (2008) The Journal of biological chemistry 283, 5677-84. PMID: 18165233
3. Mizutani, Y. et al. (2008) Journal of lipid research 49, 2356-64. PMID: 18541923
4. Spassieva, SD. et al. (2009) The Biochemical journal 424, 273-83. PMID: 19728861
5. Ohno, Y. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18439-44. PMID: 20937905
6. Tidhar, R. et al. (2012) The Journal of biological chemistry 287, 3197-206. PMID: 22144673
7. Kim, HJ. et al. (2012) Journal of lipid research 53, 1701-7. PMID: 22661289
8. Sassa, T. et al. (2016) The Journal of biological chemistry 291, 7477-87. PMID: 26887952
9. Tidhar, R. et al. (2018) The Journal of biological chemistry 293, 9912-9921. PMID: 29632068
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CERS2 Polyclonal Antibody

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