Anti-GRP78/HSPA5 Recombinant Antibody (SAA2389) (HY489013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

HY489013

abinScience

种属反应性

Human

ELISA, FCM, IF, WB

IgG1(L234A, L235A), kappa

SAA2389

Endoplasmic reticulum chaperone BiP, EC:3.6.4.10, 78 kDa glucose-regulated protein, GRP-78, Binding-immunoglobulin protein, BiP, Heat shock protein 70 family protein 5, HSP70 family protein 5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein, HSPA5, GRP78

内毒素水平

<10 EU/mg

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P11021

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000
WB	1:500-1:2000

Endoplasmic reticulum chaperone BiP (GRP78/HSPA5) is a ~72 kDa protein. Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Also binds and inactivates EIF2AK3/PERK in unstressed cells.

1. Dana, RC. et al. (1990) Endocrinology 126, 672-4. PMID: 2294010

2. Oka, OB. et al. (2013) Molecular cell 50, 793-804. PMID: 23769672

3. Evensen, NA. et al. (2013) Journal of the National Cancer Institute 105, 1402-16. PMID: 23990668

4. Cuevas, EP. et al. (2017) Scientific reports 7, 44988. PMID: 28332555

5. Ma, K. et al. (2002) The Journal of biological chemistry 277, 18728-35. PMID: 11907036

6. Ng, DT. et al. (1992) Molecular biology of the cell 3, 143-55. PMID: 1550958

7. Oikawa, D. et al. (2009) Experimental cell research 315, 2496-504. PMID: 19538957

8. Kovaleva, V. et al. (2023) Cell reports 42, 112066. PMID: 36739529

9. Kang, JM. et al. (2015) Cancer research 75, 3087-97. PMID: 26045166

For research use only

Isotype Control

Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)
Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

SDS-PAGE

SDS-PAGE for Anti-GRP78/HSPA5 Antibody (SAA2389)

产品说明书

Anti-GRP78/HSPA5 Recombinant Antibody (SAA2389).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GRP78/HSPA5 Recombinant Antibody (SAA2389) (HY489013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GRP78/HSPA5 Recombinant Antibody (SAA2389) (HY489013)

概述

图片

参考文献

产品说明书

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