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Anti-COMP Polyclonal Antibody (ARO-A13945)

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概述
货号ARO-A13945
品牌ProteoGenix
描述
Anti-COMP Polyclonal Antibody (ARO-A13945) is a rabbit polyclonal antibody detecting TSP5, Thrombospondin-5, COMP, Cartilage oligomeric matrix protein in ELISA, IHC, WB. Suitable for Bos taurus, Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Bos taurus, Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human COMP (Ser123-His240).
靶标TSP5, Thrombospondin-5, COMP, Cartilage oligomeric matrix protein
纯化方式Purified by antigen affinity column.
Accession号P49747
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cartilage oligomeric matrix protein (COMP) is a ~82 kDa protein. Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP).

1. Chen, FH. et al. (2005) The Journal of biological chemistry 280, 32655-61. PMID: 16051604
2. Koelling, S. et al. (2006) Arthritis research & therapy 8, R56. PMID: 16542502
3. Gagarina, V. et al. (2008) The Journal of biological chemistry 283, 648-659. PMID: 17993464
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-COMP Polyclonal Antibody

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