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Anti-Human BTLA/CD272 Recombinant Antibody (SAA0087) (HV375107)

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  • 100ug
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概述
货号HV375107
品牌abinScience
种属反应性Human
应用FCM
同种型IgG4, kappa
克隆号SAA0087
靶标B- and T-lymphocyte attenuator, BTLA, CD272, B- and T-lymphocyte-associated protein
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q7Z6A9
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

B- and T-lymphocyte attenuator (CD272/BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776
2. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 14652006
3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026
4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050
5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044
NoteFor research use only.
图片
  • SDS-PAGE

    SDS-PAGE for Anti-Human CD272/BTLA Antibody (SAA0087)

参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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