Anti-Human IL-1 alpha/IL-1F1 Recombinant Antibody (SAA0366), PE (HF802127)

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100T

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货号	HF802127
品牌	abinScience
种属反应性	Human
应用	ELISA, FCM
宿主	Mouse
同种型	IgG1, kappa
克隆号	SAA0366
偶联物	PE
克隆类型	Monoclonal
经测试应用	FCM
靶标	IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PE
Accession号	P01583
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. 1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902 2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369 3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581 5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Flow cytometry

Flow-cytometry using PE anti-human IL1A antibody. 5637 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human IL1A monoclonal antibody (Catalog HF802127, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human IL-1 alpha/IL-1F1 Recombinant Antibody (SAA0366), PE.pdf

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Anti-Human IL-1 alpha/IL-1F1 Recombinant Antibody (SAA0366), PE (HF802127)

概述

图片

参考文献

产品说明书

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重组蛋白

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实验相关试剂

Anti-Human IL-1 alpha/IL-1F1 Recombinant Antibody (SAA0366), PE (HF802127)

概述

图片

参考文献

产品说明书

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