Anti-Human 4-1BB Ligand/TNFSF9 Reference Antibody (CTX-471, RUO) (HC336036)

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货号	HC336036
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	CTX-471
生物活性	CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively [1]. CTX-471 binds to a unique epitope on CD137 [1]. CTX-471 (0.1-100 nM; 1, 10 ug/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro [1]. CTX-471 (i.p.; 150 ug) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors. CTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses.
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	Tumor necrosis factor receptor superfamily member 9, CD137, 4-1BB ligand receptor, CDw137, TNFRSF9, T-cell antigen ILA, T-cell antigen 4-1BB homolog, ILA
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q07011
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	CTX-471, CTX471, CTX471
背景	Tumor necrosis factor receptor superfamily member 9 (CD137/4-1BB) is a ~27 kDa protein. Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
文献	1. Ugur Eskiocak, et al. Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity. JCI Insight. 2020 Mar 12;5(5):e133647. [HC336036]
Note	For research use only. Not suitable for clinical or therapeutic use.

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD137/TNFRSF9/4-1BB (CTX-471)

产品说明书

Anti-Human 4-1BB Ligand/TNFSF9 Reference Antibody (CTX-471, RUO).pdf

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Anti-Human 4-1BB Ligand/TNFSF9 Reference Antibody (CTX-471, RUO) (HC336036)

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参考文献

产品说明书

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Anti-Human 4-1BB Ligand/TNFSF9 Reference Antibody (CTX-471, RUO) (HC336036)

概述

图片

参考文献

产品说明书

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