Anti-Human CD48/SLAMF2 Reference Antibody (SGN-CD48/SLAMF2A, RUO) (HY573016)

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概述
图片
参考文献
产品说明书

概述

货号

HY573016

品牌

abinScience

描述

Anti-Human CD48 (SGN-CD48A) (HY573016) is a research-grade recombinant antibody targeting CD48. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

种属反应性

Human

应用

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

宿主

Human

同种型

IgG

克隆号

SGN-CD48A

表达系统

Mammalian cells

克隆类型

Monoclonal

靶标

Signaling lymphocytic activation molecule 2, TCT.1, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1, CD48, BLAST1, Leukocyte antigen MEM-102, SLAMF2, BCM1 surface antigen, SLAM family member 2

内毒素水平

< 10 EU/mg

纯度

>95% purity as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

P09326

状态

Liquid

保存溶液

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

别名

SGN-CD48A, SGNCD48A, SGNCD48A

背景

CD48 antigen is a ~27 kDa protein. Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.

1. Hawash, IY. et al. (2002) Biochimica et biophysica acta 1589, 140-50. PMID: 12007789

2. Muhammad, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 7672-80. PMID: 19494291

3. Claus, M. et al. (2016) Open biology 6. PMID: 27249817

4. Brown, MH. et al. (1998) The Journal of experimental medicine 188, 2083-90. PMID: 9841922

Note

For research use only. Not suitable for clinical or therapeutic use.

图片

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD48 (SGN-CD48A)

参考文献

产品说明书

Anti-Human CD48/SLAMF2 Reference Antibody (SGN-CD48/SLAMF2A, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD48/SLAMF2 Reference Antibody (SGN-CD48/SLAMF2A, RUO) (HY573016)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD48/SLAMF2 Reference Antibody (SGN-CD48/SLAMF2A, RUO) (HY573016)

概述

图片

参考文献

产品说明书

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