Anti-Human Connexin 43/GJA1 Reference Antibody (ALMB-0168, RUO) (HB620016)

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货号	HB620016
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	ALMB-0168
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	GJAL, Connexin-43, GJA1, Cx43, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P17302
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	ALMB-0168, ALMB0168, ALMB0168
背景	Gap junction alpha-1 protein (CX43/GJA1) is a ~43 kDa protein. Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (Probable). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in the conductive system of ventricular myocardium and heart morphogenesis. 1. Ablasser, A. et al. (2013) Nature 503, 530-4. PMID: 24077100 2. Pépin, G. et al. (2020) mBio 11. PMID: 31992625 3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341
文献	1. Xianbiao Xie, et al. Durable disease control following treatment with ALMB-0168, a novel Cx43 hemichannel agonist monoclonal antibody, in femoral osteosarcoma with lung metastases after chemotherapy failure: a case report. Antibody Therapeutics, 2026, tbag007 [HB620016]
Note	For research use only. Not suitable for clinical or therapeutic use.

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CX43/GJA1 (ALMB-0168)

产品说明书

Anti-Human Connexin 43/GJA1 Reference Antibody (ALMB-0168, RUO).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human Connexin 43/GJA1 Reference Antibody (ALMB-0168, RUO) (HB620016)

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重组蛋白

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实验相关试剂

Anti-Human Connexin 43/GJA1 Reference Antibody (ALMB-0168, RUO) (HB620016)

概述

图片

参考文献

产品说明书

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