Anti-Human Glypican 3 Reference Antibody (CAT-07, RUO) (HW310056)

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货号	HW310056
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	CAT-07
生物活性	GPC3 is a cell surface heparan sulfate proteoglycan involved in cell growth and differentiation, and often studied in cancer research, particularly hepatocellular carcinoma. It is produced in mammalian cells, ensuring native-like glycosylation patterns, which is important for maintaining proper antigen recognition and functional studies.
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P51654
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	CAT-07, CAT07, CAT07
背景	Glypican-3 (GPC3/Glypican 3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. 1. De Cat, B. et al. (2003) The Journal of cell biology 163, 625-35. PMID: 14610063 2. Capurro, MI. et al. (2005) The Journal of biological chemistry 280, 41201-6. PMID: 16227623 3. Capurro, M. et al. (2014) Journal of cell science 127, 1565-75. PMID: 24496449 4. Davoodi, J. et al. (2007) Proteomics 7, 2300-10. PMID: 17549790
Note	For research use only. Not suitable for clinical or therapeutic use.

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human GPC3/Glypican 3 (CAT-07)

产品说明书

Anti-Human Glypican 3 Reference Antibody (CAT-07, RUO).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human Glypican 3 Reference Antibody (CAT-07, RUO) (HW310056)

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Anti-Human Glypican 3 Reference Antibody (CAT-07, RUO) (HW310056)

概述

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参考文献

产品说明书

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