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Anti-Human CD94 Reference Antibody (Dibotatug, RUO) (HC299016)

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  • 1mg
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概述
货号HC299016
品牌abinScience
描述
Dibotatug (HC299016) is a research-grade recombinant antibody targeting CD94. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性Human
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型IgG1-kappa
表达系统Mammalian cells
靶标Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94, CD94, KP43, KLRD1
内毒素水平< 10 EU/mg
纯度>95% purity as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q13241
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名2842038-48-4
背景

Natural killer cells antigen CD94 (KLRD1) is a ~20 kDa protein. Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.

1. Boyington, JC. et al. (1999) Immunity 10, 75-82. PMID: 10023772
2. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301
3. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576
4. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229
5. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650
6. Llano, M. et al. (1998) European journal of immunology 28, 2854-63. PMID: 9754572
7. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742
8. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220
NoteFor research use only. Not suitable for clinical or therapeutic use.
Isotype ControlHuman IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)
图片

  • SDS-PAGE

    SDS-PAGE for Research Grade Dibotatug.

  • Bioactivity

    Detects recombinant CD94 (Catalog No: HC299012) in indirect ELISA.

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CD94 Reference Antibody (Dibotatug, RUO)

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