

| 货号 | PX-P6177 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Recombinant Human CD104/ITGB4 Protein, C-His (PX-P6177) expressed in Mammalian Cells, Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 表达系统 | Mammalian Cells |
| Accession号 | P16144 |
| 蛋白长度 | Met1-Ser710 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 80.20 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | GP150, Integrin beta-4, CD104, ITGB4 |
| 背景 | Integrin beta-4 (CD104/ITGB4) is a ~202 kDa protein. Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. 1. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778 2. Fujita, M. et al. (2012) The Journal of biological chemistry 287, 12491-500. PMID: 22351760 3. Cedano Prieto, DM. et al. (2017) PloS one 12, e0184285. PMID: 28873464 |
| Note | For research use only. |

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