

| 货号 | HW502022 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Recombinant Human NKX2-5 Protein, N-GST & C-His (HW502022) expressed in E. coli, spanning Asp105-Leu207. Purity: >90% by SDS-PAGE.
Highlights
|
| 表达系统 | E. coli |
| Accession号 | P52952 |
| 蛋白长度 | Asp105-Leu207 |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 种属 | Homo sapiens (Human) |
| 性质 | Recombinant |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 预测分子量 | 40.59 kDa |
| 状态 | Lyophilized |
| 保存溶液 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | CSX, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX2-5, NKX2.5, NKX2E |
| 背景 | Homeobox protein Nkx-2.5 is a ~34 kDa protein. Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. 1. Koss, M. et al. (2012) Developmental cell 22, 913-26. PMID: 22560297 2. Pradhan, L. et al. (2012) Biochemistry 51, 6312-9. PMID: 22849347 3. Pradhan, L. et al. (2016) Biochemistry 55, 1702-10. PMID: 26926761 4. Samokhin, AO. et al. (2018) Science translational medicine 10. PMID: 29899023 |
| Note | For research use only |

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