Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody (HB973014)

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概述
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参考文献
产品说明书

概述

货号

HB973014

品牌

abinScience

描述

Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody (HB973014) is a rabbit polyclonal antibody detecting Calcitonin receptor in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CALCR/Calcitonin receptor/CT-R (Lys37-Ala152).

靶标

CT-R, CALCR, Calcitonin receptor

纯化方式

Purified by antigen affinity column.

Accession号

P30988

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Calcitonin receptor (CALCR/CT-R) is a ~55 kDa protein. G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

1. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283

2. Cao, J. et al. (2024) Biochemistry 63, 1089-1096. PMID: 38603770

3. Moore, EE. et al. (1995) Molecular endocrinology (Baltimore, Md.) 9, 959-68. PMID: 7476993

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody (HB973014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody (HB973014)

概述

图片

参考文献

产品说明书

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