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Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody (PTX19945)

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概述
货号PTX19945
品牌ProteoGenix
描述
Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody (PTX19945) is a rabbit polyclonal antibody detecting CT-R, CALCR, Calcitonin receptor in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CALCR/Calcitonin receptor/CT-R (Lys37-Ala152).
靶标CT-R, CALCR, Calcitonin receptor
纯化方式Purified by antigen affinity column.
Accession号P30988
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Calcitonin receptor (CALCR/CT-R) is a ~55 kDa protein. G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

1. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283
2. Cao, J. et al. (2024) Biochemistry 63, 1089-1096. PMID: 38603770
3. Moore, EE. et al. (1995) Molecular endocrinology (Baltimore, Md.) 9, 959-68. PMID: 7476993
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CALCR/Calcitonin receptor/CT-R Polyclonal Antibody

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